COSMOS - COordination of Standards in MetabOlomicS

Welcome to COSMOS

October 2012 marked the launch of a global effort to enable free and open sharing of metabolomics data. Coordinated by EMBL-European Bioinformatics Institute, COSMOS (Coordination of Standards in Metabolomics) has brought together European metabolomics data providers to set and promote community standards.

Whats is Metabolomics?

Metabolic processes drive physiology, and the use of metabolomics in environmental science, toxicology, food and medicine is well established and growing rapidly. Metabolomics is a way to assess the state of an organism (or collections of organisms), and involves a comprehensive set of analyses of the small molecules in cells, tissues, and body fluids.

Our aim for metabolomics standards

The partners will develop policies to ensure that metabolomics data is encoded in open standards; tagged with agreed metadata; supported by open source data management and capturing tools; disseminated in open-access databases; supported by vendors and publishers; and properly interfaced with data in other biomedical and life science e-infrastructures. Our efferts is based on previou works by Metabolomics standards initiative (MSI)

Overview of COSMOS

Overview of COSMOS initiative role in metabolomics standards, databases, data exchange and dissemination of metabolomics experiments.  Green: metabolomics labs experimental workflow from lab based data generation, metadata collection to interaction with LIMS systems. Pink: standardisation initiative and minimum information reporting agreement involved or used within the COSMOS project. Blue: Dissemination and role of journal and link to other e-infrastructures. White: databases and tools used to capture experimental data and metadata.

COSMOS overview

Linking with e-infrastructures

In addition to capturing and storing extremely large volumes of data, e-infrastructures must be capable of disseminating these data based on open and widely accepted community standards. The new project is well timed, as it coincides with the development of repositories such as MetaboLights (www.ebi.ac.uk/metabolights) and the growing support for life science e-infrastructures such as ELIXIREU-OPENSCREEN and BBMRI.

Link with other standards

The COSMOS work on standardisation aims to build on the foundational work by PSI and MSI and further develop and contribute to data exchange formats, ranging from raw data in MS and NMR, the reporting of metabolite quantification and metabolite identification, to the experimental metadata. We aim to extend the open standards for MS data exchange initiated by PSI, such as mzML and mzQuantML to meet the requirement of metabolomics experiments for reporting MS experiments.

View COSMOS Consortium partners in a larger map